Ketamine inhibits the excitability induced by formalin in spinal dorsal horn neurons of rats 氯胺酮對甲醛致痛誘導大鼠脊髓背角神經(jīng)元興奮性的抑制
Peripheral injection of formalin into plantar aspect of hindpaw produced both nociceptive behavioral responses and fos expression in the spinal dorsal horn 上述結果表明: l 、大鼠后腳掌注射福爾馬林可以同時引起大鼠的行為痛反應和脊髓背角的fos蛋白表達。
Reporting at first time the long - term potentiation ( ltp ) of c - fiber evoked field potentials in spinal dorsal horn and discovering that activation of spinal nmda , nk1 and nk2 receptors is essential for the induction of the spinal ltp C纖維誘發(fā)電位的長時程增強( ltp ) 。發(fā)現(xiàn)激動nmda 、 nk1和nk2受體是誘導ltp的必要條件;自然痛刺激可引起c纖維誘發(fā)電位的ltp ,但在正常情況下受到下行抑制系統(tǒng)的抑制。
The purpose of our present study is to verify the effect of ne on primary afferent terminal neurotrasmitter release at the synaptic level in the sg of the rat spinal dorsal horn , which might contribute to better understanding the mechanism of ne analgesic effect at spinal level 此外, ne也可能直接作用于初級傳入纖維終末。本研究的目的是在突觸水平驗證ne在大鼠脊髓sg內(nèi)對初級傳入終末釋放神經(jīng)遞質的影響,以便進一步闡明ne在脊髓鎮(zhèn)痛作用的機制。
A large number of neurons with nig - li were seen in the anterior olfactory nuclei , accumbens nucleus , septal area , 09600045 , 39970377 , 39570109 ) 9 ventral pallidum , pallidum , caudate putamen , nucleus of the stria terminalis , anterior hypothalamic area , tuber cinereum area , lateral hypothalamic area , perifornical nucleus , supraoptic nucleus , arcuate nucleus , mammillar nuclei , substatia nigra , ventral tegmental area , retrorubral area , superior and inferior colliculus , periaqueductal gray , nucleus of the solitary tract , and superficial layers of the medullary and spinal dorsal horns 大量nk3受體樣免疫反應陽性神經(jīng)元出現(xiàn)于前嗅核、伏隔核、隔區(qū)、腹側蒼白球、蒼白球、尾殼核、終紋床核、下丘腦前區(qū)、下丘腦結節(jié)區(qū)、下丘腦外側區(qū)、穹隆周區(qū)、視上核、弓狀核、乳頭體、黑質、腹側被蓋區(qū)、紅核后區(qū)、上丘和下丘、導水管周圍灰質、孤束核、及延髓和脊髓背角淺層。